NCOG-10. SURGERY FOR RECURRENT GBM: A RETROSPECTIVE CASE-CONTROL STUDY

Abstract OBJECTIVE The role of surgery in recurrent GBM remains a controversial topic. goal this study was to perform case-control analysis including time tumor recurrence as an additional prognostic factor order determine which patients benefit most from repeat surgery. METHODS Our brain database reviewed over ten-year period for all adult (≥ 18 years old) with primary IDH wildtype that received disease. These were then age, sex, and treatment-matched case-controls our institution medical therapy RESULTS A total 174 included the study, 87 (surgery cohort) did not receive (non-surgery cohort). cohort had longer overall survival (p = 0.0003) post 0.001) than non-surgery cohort. When split into two groups based on recurrence, long group ( > 6 months) demonstrated significantly increased compared short < 0.0001). Multivariate both cohorts independently significant after adjusting KPS, CONCLUSIONS Surgery leads improved independent recurrence. Patients greater months